Leonardo DiCaprio Dr. Randall Mindy Jennifer Lawrence Kate Dibiasky Meryl Streep President Janie Orlean Cate Blanchett Brie Evantee Rob Morgan Dr. Clayton 'Teddy' Oglethorpe Jonah Hill Jason Orlean Mark Rylance Peter Isherwell Tyler Perry Jack Bremmer Timothée Chalamet Yule Ron Perlman Benedict Drask Ariana Grande Riley Bina Kid Cudi DJ Chello Himesh Patel Phillip Melanie Lynskey June Mindy Michael Chiklis Dan Pawketty Tomer Sisley Adul Grelio Paul Guilfoyle General Themes Robert Joy Congressman Tenant Lance A. Williams Daniel Hettienne Park Dr. Calder Rena Maliszewski Anchor Reporting On Colon Conor Sweeney Marshall Mindy Ross Partridge Keith Ollens Liev Schreiber Bash Narrator (voice) Meara Mahoney-Gross Isherwell Child Aide Annette Miller Mrs. Tanken Meghan Leathers Media Quant Sarah Silverman Sarah Benterman Jon Glaser Meow Man Frank Ridley Flight Director Anderson Chris Evans Devin Peters (uncredited)