Millie Bobby Brown Enola Holmes Henry Cavill Sherlock Holmes Sam Claflin Mycroft Holmes Helena Bonham Carter Eudoria Holmes Louis Partridge Lord Tewkesbury Adeel Akhtar Lestrade Fiona Shaw Miss Harrison Frances de la Tour The Dowager Burn Gorman Linthorn Susan Wokoma Edith Claire Rushbrook Mrs. Lane David Bamber Sir Whimbrel Hattie Morahan Lady Tewkesbury Gaby French Seamstress Paul Copley Station Master Ellie Haddington Miss Gregory Alex Kelly Miss Gregory II Dempsey Bovell Fleet Street Hawker Neil Bell Constable David Kirkbride Agitator Delroy Atkinson Porter Gianni Calchetti Roy (uncredited)