Tom Hanks Fred Rogers Matthew Rhys Lloyd Vogel Chris Cooper Jerry Vogel Susan Kelechi Watson Andrea Vogel Maryann Plunkett Joanne Rogers Enrico Colantoni Bill Isler Wendy Makkena Dorothy Vogel Tammy Blanchard Lorraine Vogel Noah Harpster Todd Carmen Cusack Margy Whitmer Christine Lahti Ellen Maddie Corman Betty Aberlin Gretchen Koerner Doctor Jessica Hecht Lila Vogel Di Zhu Waitress Krizia Bajos Argentinian Girl (uncredited) Francesca Calò Train Passenger (uncredited) Crystal Lonneberg Subway Punk (uncredited) Joe Fishel Journalist (uncredited) Michael Masini Richie (uncredited)