Rebel Wilson Natalie Liam Hemsworth Blake Adam Devine Josh Priyanka Chopra Isabella Betty Gilpin Whitney Brandon Scott Jones Donny Tom Ellis Dr. Todd Jennifer Saunders Natalie's Mother Big Jay Oakerson Gary Michelle Buteau Martina Marcus Choi Cute Guy Hugh Sheridan Cute Guy Luciano Acuna Jr. Cute Guy Raymond Anthony Thomas Boss Zach Cherry Co-Worker Sandy Honig Co-Worker Rosemary Howard Co-Worker Ron Nakahara Co-Worker Shyrley Rodriguez Young Girl Lorrie Odom MTA Worker Joe Towne Normal Dude (Rich) Shonali Bhowmik Bridesmaid Sawandi Wilson Hot Doctor Seth Barrish Haggard Doctor Bowen Yang Donny's Guy Doris McCarthy Homeless Lady (uncredited) Nora Sommerkamp Office Worker (uncredited) Esteban Benito Officer Handsome