Annabelle Wallis Madison Mitchell Maddie Hasson Sydney Lake George Young Detective Kekoa Shaw Michole Briana White Detective Regina Moss Jacqueline McKenzie Dr. Florence Weaver Jake Abel Derek Mitchell Ray Chase Gabriel (voice) Marina Mazepa Gabriel Jean Louisa Kelly Jane Doe / Serena Susanna Thompson Jeanne Ingrid Bisu Winnie Zoë Bell Scorpion Christian Clemenson Dr. Victor Fields Mckenna Grace Young Madison Mitchell Jon Lee Brody Officer Lee Paula Marshall Beverly Woods Patrick Cox Mr. Stanley Rachel Winfree Mrs. Ryerson Paul Mabon Orderly Ruben Pla Officer Rubin Patricia Velásquez Nurse Gino Montesinos Seattle Police Officer Christina Veronica Holding Cell Inmate (uncredited)