Tom Hanks Otto Anderson Mariana Treviño Marisol Rachel Keller Sonya Manuel Garcia-Rulfo Tommy Cameron Britton Jimmy Kailey Hyman Barb Mike Birbiglia Real Estate Agent Joe Fishel Army Doctor Truman Hanks Young Otto Anderson Juanita Jennings Anita Kelly Lamor Wilson Shari Kenzie John Higgins Hardware Store Clerk Carl Clemons Stimco Steel Worker Alessandra Perez Abbie Ira Amyx Otto's Father Greg Allan Martin Lucas Bryant Carroll Train Conductor Jon Donahue Officer Dudley Gina Aponte Train Rider (uncredited)